Hypothalamic modulation of splenic natural killer cell activity in rats.
نویسندگان
چکیده
منابع مشابه
Modulation of Natural Killer Cell Activity
Natural killer (NK) cells are a heterogenous subpopulation of peripheral blood lymphocytes (PBL) that have the ability to kill various tumors and tumor cell lines in the absence of prior sensitization. These cells have generated considerable interest and have been implicated in natural resistance to tumors,'-5 resistance to viral infection:-7 transplantation rejection,'** and immunoregulation o...
متن کاملHypothalamo-Sympathetic Modulation of Splenic Natural Killer Cell Activity: An Involvement of Brain Cytokines
The sympathetic nervous system is one of the multiple channels that communicate between brain and immune system. In the brain-immune interactions, cytokines produced in the periphery and brain during inflammatory as well as noninflammatory stress play important roles as signal molecules. For example, central administration of interleukin-1 (IL-1 ) and interferon(IFN) suppresses splenic natural ...
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This study investigates the effect of steroid and polypeptide hormones on human NK cell activity in vitro. Solutions of hormones were incubated with normal peripheral blood cells in a 4 h cytotoxic assay against the NK-sensitive erythromyeloid cell line K562. The steroid hormones oestradiol, progesterone and testosterone did not exhibit a significant effect on K562 lysis at concentrations withi...
متن کاملIncreased Natural Killer Cells Activity in Schizophrenic Patients
Background: Schizophrenia has been associated with altered immunity. Different studies regarding natural killer cell activity (NKA) in schizophrenic patients have shown inconsistent results. Objectives: To evaluate NK cell activity in schizophrenic patients in comparison with healthy control individuals. Methods: 30 medication-free schizophrenic patients and 41 healthy sex, age and smoking st...
متن کاملModulation of murine natural killer cell activity in vitro and in vivo by recombinant human interferons.
The ability of two subtypes of recombinant human alpha interferons (IFN), rIFN-alpha A and rIFN-alpha D, and two intramolecular hybrids, rIFN-alpha A/D and rIFN-alpha D/A, to modulate murine natural killer (NK) cell activity in vitro and in vivo was examined. The cytotoxic activity of murine spleen cells was markedly augmented by rIFN-alpha A/D following in vitro incubation, while the other IFN...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1993
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1993.sp019898